Two techniques were used in the determination of the mass of active ingredient present in the tablets. The first was the extraction and purification of paracetamol from tablets. The second was an acid catalysed hydrolysis under reflux followed by titrations against ammonium cerium sulphate.
The use of the melting point allowed the purity of the paracetamol to be determined.
The extraction and purification of paracetamol
This procedure extracted paracetamol from the tablets by crystallisation. The paracetamol tablets were crushed and dissolved in propanone at a raised temperature; this decreased the time required for the paracetamol to dissolve. The binding agents and fillers in the tablet are insoluble in propanone however the paracetamol is soluble. This results in the paracetamol forming a solution in the propanone while the other components of the tablet are left as insoluble residue. The solution was filtered to remove the residue. The filtrate was left to evaporate forming crystals of paracetamol.
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